Gene therapy may be classified into the two types (1) germ line gene therapy and (2) somatic cell lgene therapy. In case of Germ line gene therapy germ cells sperms or eggs integrated into their genomes. Therefore, the change dur to which are ordinarily integrated into their genomes. Therefore, the change due to therapy is heritable and passed onto later generations. This approach theoretically is highly effective in counteracting the genetic disorders. However, this option is at least for the present for application in human beings for a variety of technical and ethical reasons.
In somatic cell gene therapy the gene is introduced only in somatic cells, especially of those tissues in which expression of the concerned gene is critical for health. Expression of the introduced gene relives symptoms of the disorder but this effect is not heritable as it does not involve the germline. Somatic cell therapy is the only feasible option, and clinical triasl have already started most for the treatment of cancer and blood disorders. This approach is divided into two categories.
(1) Augmentation therapy
(2) targetted gene transfer.
In somatic cell gene therapy the gene is introduced only in somatic cells, especially of those tissues in which expression of the concerned gene is critical for health. Expression of the introduced gene relives symptoms of the disorder but this effect is not heritable as it does not involve the germline. Somatic cell therapy is the only feasible option, and clinical triasl have already started most for the treatment of cancer and blood disorders. This approach is divided into two categories.
(1) Augmentation therapy
(2) targetted gene transfer.
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